Vitamin C Treatment for Coronavirus Under Investigation

Vitamin C Treatment for Coronavirus Under Investigation

February 4, 2020, researchers at Zhongnan Hospital in China announced they will investigate the effectiveness of vitamin C infusion for the treatment of severe COVID-19 infected pneumonia.¹⁴
Many of the deaths associated with this viral pneumonia appear to be due to septic shock,¹⁵ and studies suggest high-dose vitamin C infusions can improve outcomes in cases of sepsis¹⁶ and respiratory infections.¹⁷ As noted in the Zhongnan Hospital's study description:¹⁸

"Viral pneumonia is a dangerous condition with a poor clinical prognosis … Vitamin C, also known as ascorbic acid, has antioxidant properties. When sepsis happens, the cytokine surge caused by sepsis is activated, and neutrophils in the lungs accumulate in the lungs, destroying alveolar capillaries.

Early clinical studies have shown that vitamin C can effectively prevent this process. In addition, vitamin C can help to eliminate alveolar fluid by preventing the activation and accumulation of neutrophils, and reducing alveolar epithelial water channel damage.

At the same time, vitamin C can prevent the formation of neutrophil extracellular traps, which is a biological event of vascular injury caused by neutrophil activation."

The researchers intend to treat patients with 24 grams of IV vitamin C per day for seven days at a speed of 7 milliliters per hour. The placebo group will receive an IV of normal saline.
The primary outcome measure will be the number of days without ventilation support during 28 days of hospitalization. Secondary outcome measures will include mortality, ICU length of stay, the rate of CPR required, vasopressor use, respiratory function, sepsis-related organ failure and more.
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